6 Benefits of S-Adenosylmethionine (No.1 Super Potent)

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S-adenosylmethionine (SAMe) is not found in food, but the methionine amino acid is naturally found in the tissues and fluids in the body. SAMe plays a role in the immune system to maintain cell membranes, and help to produce and break up brain chemicals, such as serotonin, melatonin, and dopamine. SAMe helps the production of neurotransmitters in the brain to affect mood and feeling overall. It works with vitamin B12 and folate or vitamin B9. Either vitamin B12 deficiency or folic acid can reduce SAMe levels in your body.

SAMe is believed to help relieve the pain of osteoarthritis. Even in Europe, over the years has been used to reduce depression. Researchers also have examined the use of SAMe in the treatment of fibromyalgia and liver disease. Many early studies used SAMe given intravenously or as an injection. Only recently researchers could see the effects of taking SAMe. Most importantly the ability of SAMe to slow and suppress endogenous retroviral genes.

1. Schizophrenia Remedies

SAMe than as a standard antipsychotic medication, was also able to improve the quality of life (QLS scale rating) and reduce aggressive behavior (assessed with a new clear Aggression Scale) in a subset of patients with schizophrenia. If using a placebo decreased the risk by 43% , SAMe recorded a decrease of 77%. This is because they enzyme COMT polymorphism is associated with aggressive behavior in Schizophrenia, very effectively lowered by the consumption of SAMe.


800 mg daily for 8 weeks

Side effect

However, if you are a person with acute depression such as bipolar disorder (manic depression) and Parkinson’s disease. You are not allowed to consume SAMe supplements without consulting your doctor first.

2. Depression

Although it is believed to reduce depression, how SAMe in reducing depression remains a mystery. Only the strongest allegation is SAMe able to increase the amount of serotonin in the brain such as some antidepressants do.

Some research indicates that SAMe more effective than placebo in treating mild to moderate depression and as effective as antidepressants without side effects such as headache, insomnia, and sexual dysfunction. Besides antidepressants tend to take 6 to 8 weeks to start working, while SAMe appears to start faster.


To alleviate the Depression, the number of consumption is between 800 to 1,600 mg of SAMe per day, taken twice a day at morning and afternoon.

Side effect

Basically, still need further research on the use of SAMe for depression treatment. However, if you are a person with acute depression such as bipolar disorder (manic depression) and Parkinson’s disease. You are not allowed to consume SAMe supplements without consulting your doctor first.

3. Osteoarthritis

SAMe may reduce pain and inflammation in the joints, it is because they were able  to pair up the SAMe cartilage. SAMe supplement is as effective as anti-inflammatory drugs (NSAIDs, such as ibuprofen and naproxen) in adults with hip, knee, or spine osteoarthritis, reducing morning stiffness, improve range of motion, reduce pain and swelling, and increase the speed walk. Moreover, SAMe has fewer side effects than NSAIDs.


For Osteoarthritis, total consumed is between 600 to 1,200 mg a day and divided in 2 to 3 doses.

Side effect

SAMe directly does not give adverse effects on the use for osteoarthritis, it’s just that SAMe can result in headache and dizziness. Keep in mind that SAMe does not work on the knee osteoporosis.

4. Heart and Hepatology

People with liver disease are often unable to synthesize SAMe in their bodies. Preliminary studies have shown that taking SAMe can help to treat chronic liver disease caused by drugs or alcohol. SAMe can help to reduce levels normalize liver enzymes in people with liver disease.

  • Fatty Liver and Cirrhosis

SAMe is able to normalize the measured Glutathione levels in erythrocytes or red blood cells, liver damage due to modifications in sulfur metabolism, protect the liver from damage.


treatment of people with cirrhosis of the liver over 2 years treaten by SAMe 1200mg daily can reduce the level of tansplantation liver cirrhosis or death form from 29% to 12%.

  • liver enzyme


SAMe 800 mg for 8 weeks recorded a slight increase serum ALT are known in magnitude (22%).

Side effects

The use of SAMe for the treatment of liver and hepatology according to the dose will not provide any side effects, it’s just that sometimes these drugs cause nausea, vomiting, and stomach pain in patients.

5. fibromyalgia

SAMe can be effective in reducing the fibromyalgia symptom, including pain, fatigue, morning stiffness, and feelings of depression. However, most studies using injectable of SAMe form. Among the studies that examined the dose of oral SAMe, some found it was effective in reducing these symptoms while others found no benefit.


To treat fibromyalgia, SAMe dosage is between 400 mg, taken 2 times a day for 6 weeks.

Side effects

The use of SAMe for fibromyalgia sometimes have an effect on Increased sweat.

6. Other benefits

In addition to some of the benefits above, SAMe is also effective for:

  • Inhibit tumor cells cancerous.
  • Other studies show that the drug levodopa (L-dopa) for Parkinson’s disease can reduce levels of SAMe in the body, which can lead to depression and increase the side effects of L-dopa.
  • SAMe may lower blood sugar levels and can amplify the effects of diabetes drugs, which increase the risk of hypoglycemia.


  • SAMe should not be given to children without the supervision of doctor.
  • Side effects may include dry mouth, anxiety, nausea, gas, excitement, diarrhea, headache, anxiety, and insomnia.
  • SAMe large doses can cause mania (abnormal moods).
  • Avoid consumption of SAMe for under- and lactating mothers.
  • People who taking SAMe might want to take a multivitamin containing folic acid and vitamins B12 and B6.
  • People with bipolar disorder should not take SAMe because it may worsen manic episodes.
  • Do not take SAMe with Dextromethorphan, Meperidine (or Demerol), Pentazocine (or Talwin), Tramadol (or Ultram) and antidepressants.

Benefits Of S-Adenosylmethionine as some remedies is very proven and uses around the world.